"Invention is the most important product of man's creative brain. The ultimate purpose is the complete mastery of mind over the material world, the harnessing of human nature to human needs.” — Nikola Telsa



Current medical therapy is not without problems. Commonly used small molecule and antibody drugs both have multiple limitations.


There are several limitations of small molecule drugs:

  • Small surface area exposure can limit binding affinity and specificity

  • Poor modulation of protein-protein Interactions; Most designs cannot incorporate avidity or allosteric modulation

  • Need for optimizing ADME

Meanwhile, there are also multiple limitations of antibody biologics as well:

  • Biophysical properties prevent cell penetration and limit tissue penetration

  • Many uncertainties in the drug product CMC and immunogenicity

  • Manufacturing process complexity and high cost

To respond to this unmet medical need, Tavotek has created TavoELITE™, a novel platform that goes after intracellular targets for the treatment of cancer and other diseases.


  • Enhanced target cell-specific internalization

  • Efficient endosomal escape for intracellular target

  • Intracellular target intervention by protein-protein interaction (modulation, inhibition or degradation) and/or through RNA modulation (silencing or delivering)

Building Blocks

  • Novel molecular constructs that enhance target cell-specific internalization (e.g., VHO and VHO-Fc)

  • CPP, EDD, circular RNA, etc. that enable efficient endosomal escape

  • Utilizing enhanced Fc function or by conjugating small molecule engager to enable ubiquitin protease-mediated degradation

  • Fab, scFv, peptide, or small molecule that specifically interact with the intracellular protein target

  • Shuttled gene therapy components 

727 Norristown Road, 3 Spring House Innovation Park Suite 101, Lower Gwynedd, Pennsylvania 19002

China. Suzhou. Suzhou Industrial Park. Unit 405, Building C2, No. 218, Xinghu Street

© 2023 Tavotek Biotherapeutics All rights reserved.   (267) 405-9426

© 2023 Tavotek Biotherapeutics All rights reserved.(267) 405-9426